Polynucleotides For Hydrated, Youthful Skin

Made from DNA fragments extracted from fish, polynucleotide injections like Plinest stimulate the skin’s own regeneration process for anti-ageing results.

What are Polynucleotides?

Polynucleotides are purified DNA strands sourced from salmon or trout sperm. When injected into the skin, these biocompatible DNA fragments signal the body’s cells to boost collagen and elastin production. As a result, polynucleotide injections deliver noticeable firming, tightening, and rejuvenating effects.

Beyond their cosmetic benefits, polynucleotides promote the skin’s natural repair processes – hence termed ‘biostimulators‘. They stimulate fibroblast cells and improve wound healing. The injections also hydrate skin from within while fighting free radical damage with potent antioxidants. Overall, polynucleotide treatments leave you with visibly smoother, plumper, and glowing skin.

How do Polynucleotides work?

Rather than fill out the skin like dermal fillers, polynucleotides encourage your body’s fibroblasts to multiply and produce more collagen on their own. The DNA fragments safely integrate within the skin and trigger skin cell regeneration for long-lasting, natural-looking results.


At Eagle Aesthetics & Surgery, we offer a type of highly purified PN injectable under the brand Plinest

Fight signs of ageing through bio-revitalisation

Encourage fibroblast regeneration and collagen production

Improve skin hydration and elasticity

Restore a glowing, radiant complexion


Rejuran-S is another polynucleotide product offered, well-suited for acne scars. This is because the increased collagen synthesis helps to fill out acne scars that are depressed, smoothening the skin surface.

Stimulate collagen production

Enhance skin healing

Improve skin hydration and elasticity

Reduce inflammation and hyperpigmentation

How is the Polynucleotide (Plinest) Treatment done?

After application of local anaesthesia, multiple small injections are administered superficially using fine needles or cannulas. Some blebs or mild swelling may occur, which goes away as the product is absorbed into the skin.

Typically, benefits will take a few weeks to be visible as the polynucleotides work at the cellular level to take effect. Some improvement may be seen after 2-3 weeks, with full effects visible a few months down the road.

Areas commonly treated include the under eyes, cheeks, jawline, and neck. Polynucleotides are not meant as a replacement for fillers or BTX, instead they improve skin texture and function.

Are there risks associated with Polynucleotides?

The safety of polynucleotide injections depends greatly on both the qualifications of the administering physician and the quality of products used. When performed by a trained, experienced professional, reputable polynucleotide treatments present a low risk profile. 

However, as with any medical procedure, patients should understand potential complications, such as:

  • Temporary side effects like bruising or swelling
  • Small risk of infection
  • Allergic reaction to ingredients

Be sure to go to a reputable and credible provider for polynucleotide treatments and other cosmetic procedures.

Frequently Asked Questions

Most patients see a gradual improvement over 2-3 months as collagen builds up. Results include smoother skin texture and a reduction in the depth/appearance of wrinkles and folds.

Most patients maintain a level of improvement for 6-9 months on average. Additional “touch-up” treatments may extend the timeline.

While polynucleotides  and skin boosters both offer rejuvenating effects, they differ in how they work and the timeline of their results.

Skin boosters deliver visible, immediate hydration for a short-term glow that can refresh one’s complexion prior to important events. Their effects are apparent within days but may only last a few months.

Polynucleotides stimulate the body’s natural collagen production over a longer period. Though changes emerge gradually over weeks, their influence can meaningfully reduce fine lines when used as part of an ongoing rejuvenation routine.

By assessing patients’ individual goals, our doctors can determine whether fast but fleeting skin boosters or a commitment to polynucleotide therapy best suits their needs. Offering a range of options diversifies treatments and caters to patients with differing goals. Both deliver significant rejuvenating benefits through diverse yet effective mechanisms of action.

Polynucleotides like plinest is versatile and well-tolerated, which allows it to be easily combined with many aesthetic treatment protocols. It also has minimal downtime.

It can be combined with procedures like laser resurfacing, radiofrequency microneedling, dermal filler injections, chemical peels, and botulinum toxin treatments to further enhance outcomes.

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